With the goal of inspiring the bioengineering of multifunctional biomaterials based on intrinsically-disordered proteins (IDPs), we synthesized recent multidisciplinary progress in programming and exploiting the bio-functionality of disordered protein-polymers (IDPPs), a class of engineered repeat IDPs with stimuli-responsive properties. We advance the premise that recent efforts to dissect the conformational dynamics and functionality of IDPs are providing a wealth of information to propel the accelerated engineering of high-value biotechnologies and biomaterials.
The paper just appeared online in Advanced Drug Delivery Reviews. The work was led by Maria Camila Giraldo-Castaño, with contributions from Alexa Avecilla, Kai Littlejohn and Natalia Barrera-Villamizar.